In present time Essay Example for Free

In present time Essay In present time, women have obtained more freedom to express their thoughts  and more privileges to achieve their goals. Their social status had a qualitative leap in the United States compare with the last couple of centuries; this subversion will continue lead women to enter a world which their talent and ability can be completely recognized. Different from today’s value, women who lived in previous centuries do not have the rights to do things the way they prefer. Social morality and family obligation force them to obey others and renounce independent. This inveterate principle stifled generations of women and their freedom. Both works include The Revolt of â€Å"Mother† and A New England Nun by Mary Wilkins Freeman showcased that in order for a woman to regain the pleasures in her life, she has to be intrepid and determined under certain social pressure. By descripting both characters Louisa and Sarah’s detailed inner world such as their characteristics and other social aspects such as other’s judgments, Mary Freeman provided the reader with vivid sense of equality that led the society into deep consideration and introspection of why feminism is necessary. Bothworksservedasimilarpurpose,tospreadtheconceptoffeminism,but with different approaches due to different social status of both characters in The Revolt of â€Å"Mother† and A New England Nun. Mary Freeman’s Puritan way of living had a huge impact on how she considers the world differently. In The Revolt of â€Å"Mother†, Mary Freeman portrayed a married woman, Sarah Peen, who has been serving for the 1 Sun family for forty years without any complain, had an emotional outburst about the new farm that her husband was building. Her husband, Adoniram, promised Sarah that he would build her a house when they are financially improved. Instead of building her the dream house, he planed to build another farm without informing her. She then decided to move into the new barn to live when her husband had gone out. (Freeman) In Freeman’s other work, A New England Nun, she depicted Louisa Ellis, a woman who waited for her fiancà ©Ã¢â‚¬â„¢s returning from Australia for fifteen years, had decided to end the relationship with him after she hears that he has no love to her. (Freeman) This may be an excuse for her to escape from the relationship that will eventually force her to ingratiate others and put her own needs second. However, Louisa made up her own mind and went the way she preferred. By observing the behaviors of these two characters, it is certain that both of them have their own belief and rule of life that is beyond reach. Sarah Peen wants changes in her life, changes that can overturn her current life. As the story begins, Sarah provides service for her family everyday hoping to move into a new house like her husband promised her to. (Freeman 666) Moreover, She is a woman with ideas and goals. Freeman writes, â€Å" ‘There ain’t no use talkin’, Mr. Hersey,’ says she. ‘ I’ve thought it all over an’ over, an’ I believe I’m doin’ what’s right. I’ve made it the subject of prayer, an’ it’s betwixt me an’ the Lord an’ Adoniram. There ain’t no call for nobody else to worry about it.’† (670) This is what Sarah replied to the minister when he came to convince Sarah not to disobey her husband. After 2 Sun forty years of waiting, Sarah decides that she is strong enough to take a stand for the change. She is surprisingly independent and rebellious. Her rebellion does not only exist for against her husband, but also for against the social role that she is suppose to play as a submissive wife. Even though she accepts her responsibilities as a wife and a mother, her determination and resistance to the power of tradition was never stifled. As a wife whose husband often ignores, she opposes her husband’s male dominance over hers and remains integrity, courage, and privation overall. However, Louisa Ellis from A New England Nun had an opposite lifestyle with Sarah has but the same perception of individualism. LouisaEllis,unlikeSarah,isafraidofchangesandunknowns,butshestill forwards her life regarding what others would think. Her engagement with Joe Dagget is full of uncertain. Freeman did not deliver Louisa’s remorse of engagement directly. Instead, she implied some details to inform her readers that Louisa is satisfied with her own life by enlarging her trivial acts such as using china. Freeman writes, â€Å"Louisa used china everyday – something which none of her neighbors did. They whispered about it among themselves.† (654) This indicates that Louisa lives her own quiet life and enjoys her own pleasure. All of sudden, Joe Dagget shattered Louisa’s peace, the peace that only belongs to her. Freeman writes, â€Å"He remained about an hour longer, then rose to take leave. Going out, he stumbled over a rug, and trying to recover himself, hit Louisa’s work-basket on the table, and knocked it on the floor.† (654) All his acts reminded Louisa that she has to put herself at second after their marriage and 3 Sun renounce her independent. She then realized that she wants to be who she is, not to be a wife of a man who she has less love with. She is mainly descripted as a dainty and methodical woman; she pays most of her attention to details and perfections. Therefore, after she overheard that Joe has no love to her either, she quickly made her decision that she is not going to marry Joe because she desires for remaining alone. (Freeman 661) Even though both Sarah and Louisa have similar lives, they have different characteristics. Both women have comparable lives. Louisa and Sarah both reside at rural area where men do most of the working, and women do most of the housework. (Freeman 654, 662) This is one of the reasons why both characters chose to make astonishing decisions of their own. Initially, they must identify themselves, and then make decisions regarding tradition that has been persisted for centuries. Both women are also conflicted with men in a relationship that lasted a long period of time. Louisa waited her fiancà © for fifteen years while Sarah waited forty years to move forward of her life. Eventually, they both have achieved their goals and won the victories. However, in A New England Nun, the social influence is less conscious. There is less portrayal of judgments made by other members in the society. Instead, Freeman inserted implicit approach such as Louisa’s pet, Caesar, to display how the community would tie her up in a promise of engagement. (Freeman658) Different from Louisa, the community that Sarah lived in for forty years does not allow her to determine her own life. Her husband and son ignore her by not answering her questions; the minister 4 Sun came to her house to criticize her â€Å"inappropriate† conduct; people in her community also talks about her rebellion against her husband. Freeman displayed how they treat Sarah like a woman who should not have equal rights and dignity with a straightforward picture. Consequently, the two characters Sarah Peen and Louisa Ellis in both Freeman’s work The Revolt of â€Å"Mother and A New England Nun overcame dilemmas effectively. Both stories are relevant to the concept of feminism, which is equal justice between both sexes. The endings are similar: Sarah moved to the new barn while Louisa lived her own stilled life. Their encounters influenced and united generations of women to go forward together and break rules and instructions in order to live in freedom. Works Cited Freeman, Mary. A New England Nun. The Norton Anthology of American Literature. Gen. ed. Nina Baym. 8th ed. Vol. C. New York: Norton, 2013. 653-661. Print Freeman, Mary. The Revolt of â€Å"Mother†. The Norton Anthology of American Literature. Gen. ed. Nina Baym. 8th ed. Vol. C. New York: Norton, 2013. 662- 672. Print 5

Compare and Contrast at least three of Fanthorpes poems Essay Example for Free

Compare and Contrast at least three of Fanthorpes poems Essay Fanthorpes poems: Half-past Two, Dear Mr Lee, and You will be hearing from us shortly offer us an insight into the views and thoughts of Fanthorpe, as well as making the reader think about their own preconceptions. She does this by making quirky and sometimes satirical poems, which seem almost like prose. Fanthorpes aims are unmistakable; her way of inviting the reader to look at life through her tongue-in-cheek writing makes people question their belief on the matter(s) that the poem explores. For example in Half-past Two the poet queries the strange idea of time. Adults see time as a number organised into a sequence that continues through out the day with out stopping. However in this poem Fanthorpe shows that children develop a different sense of time, almost like a dream world where time, as we know it, stops to exist. She also delves into the way that children see time as an event not a number, for example timeformykisstime. Likewise, in Dear Mr Lee, the poet disputes the way of teaching English, stating that the way teacher deconstruct and analyse poems makes it impossible for the piece to be appreciated for its face values. Similarly, You will be hearing from us shortly dissects the truth about interviews and the way that pressure in an interview can make the interviewee feel looked down on and prejudged. The poem is slightly satirical towards the end, but this only exaggerates the point that Fanthorpe is trying to convey. While under pressure, interviewees can hallucinate in a surreal manner. For example, And you were born-? Yes pity. Overall, the aims of all three poems suggest that Fanthorpe has some strong views about things we dont really see as serious issues but do affect people. Technique plays a big role in all of Fanthorpes poems, especially You will be hearing from us shortly, where the text aligned on the right indicates what the interviewer is thinking at that point in the interview. This is unique to Fanthorpes poems. Likewise in Dear Mr Lee irregular and haphazard line endings and even a P.S. in the poem contributes to the idiosyncratic nature of it. However in Half-past Two there are well-organised stanzas, typical of the common types of poem. Capital letters are used to exaggerate or highlight an important idea that Fanthorpe wants to be recognised, for example on Her desk represents the way the child imitates something said to him. Another variant from the norm in all three poems is the use of brackets or italic writing to represent either private thoughts or another voice. During the three pieces various voices are regularly used; the poet will do this to show either a different viewpoint or the words of a narrator. In the poem Half-past Two voices are used extensively to represent what the child was thinking, what the teacher said and also the narrating. During Dear Mr Lee there seems to be no arrangement in the text at all, however it does resemble a prose letter. However, looking more closely, the poem seems to represent the childs feelings about teaching methods. Voices in this poem seem to consist of the childs thoughts and her teachers remarks. However in You will be hearing from us shortly the only voice is of the interviewer(s). I imagine Fanthorpe does this so that the reader can add in his or her own response to the observations of the interviewer. Fanthorpes style is very prose-like and the colloquial nature invites the reader into a new dimension of humour. The register in all three poems is varied, for example in Dear Mr Lee goes from, youd know its lived with me, stained with Coke and Kitkat too, good at terse and cogent. This varied approach to the poem may be due to the different voices that Fanthorpe puts in. All three poems especially contain a satirical and sarcastic tone, and towards the end of You will be hearing from us shortly there is an almost surreal and dreamy feel to the tone. However all the poems, as well as having humour and tongue-in-cheek style, also harness a serious intention. For example in You will be hearing from us shortly, even though it is quite funny, the way you can be looked down on in as an interviewee is a prejudice. For example the interviewer says And now a delicate matter: your looks. Do you appreciate this work involves contact with the actual public? This is clearly is meant to be a realistic event so that Fanthorpe can insight the reader to believe that prejudice does happen. Generally all the poems are very well written, however close analysis reveal even more about the poets way with words. In Half-past Two the last stanza is a brilliant description of the way that a child can slip into the clockless land of ever, and time hides waiting to be born. This end fraction of the poem portrays the childs dream world and how there is no time until the child is taught how to read time and it is then that time, as adults know it is born. In You will be hearing from us shortly the poet could not only be referring to the way that interviewers look upon interviewees, but how candidates assume surreal events will occur in the interview. For example it is very unlikely that an interviewer would comment on the very existence of an interviewee. During Dear Mr Lee Fanthorpe takes on the role of a child and doesnt tell the reader she has done this but instead writes like one. She achieves this by having no indents, no punctuation, random line lengths, no rhythm or rhyme and no paragraphs. For example there is not one full stop until the forty-ninth line. Writing like a child makes the reader think that the poem is being told by a child. To conclude, the three Fanthorpe poems looked at in the Essay help us to understand the way that Fanthorpe regards incidents happening in the world today. It also uses a colloquial tone that provides a jovial piece to read as well as getting a serious point through. All in all the prose-like texts let the reader enjoy an idiosyncratic and meaningful set of poems.

Bipolar Disorder: Roles of neurotransmitters and signal transduction

Bipolar Disorder: Roles of neurotransmitters and signal transduction This systematic review provides a critical insight into the biochemical aetiology of bipolar disorder. It presents an overview of the findings collected from various researches which investigate the abnormalities in neurotransmitter systems and signal transduction system. The results confirm hypothesises established in earlier theories of the causes of Bipolar disorder form pharmacological investigations. However these results are correlation, culmination of these variables and others such as environmental and genetics may influence the development of bipolar disorder. Aims, Evaluation, implications and limitations of these studies are included in this review. Bipolar disorder also known as manic depressive disorder can have a negative effect on an individuals mood, relationships, and everyday life. This disorder can affect the cognitive functions and is known to impair cognitive areas such as attention, executive functions, learning, memory and psychomotor speed. Bipolar usually develops in late teens or early adulthood but can sometimes develop early on in childhood. Symptoms usually build up later on in life. The disorder can lead to poor school performance, damaged social lives and jobs. . It affects both sexes equally in all age groups and approximately 3-5% of the general population are affected (Baldessanni, 2002). Bipolar disorder is the most rigorous forms of all mental illness and is characterized by swinging moods .The clinical course of illness can vary from a mild depression to a rigorous form of mania. The condition has a high rate of recurrence and can lead to suicide if left untreated (15% of patients) this is most likely t o occur during a depressive state. Bipolar disorder is a severely debilitating brain affective disorder which has had very little extensive research conducted on; in particular the biochemistry component of the disorder has had relatively few research studies compared to genetics. Due to its high rate of suicide and reoccurrence rate it is essential to develop effective treatment to prevent the two main problems of bipolar disorder (Shastry, Burker S, 2005). The manifestations of the symptoms are often mistaken for unipolar depression (31%) and therefore misdiagnosis of bipolar often occurs (Berk et al, 2006). Research into the neuropathological aspect paves the way for more future developments in viable treatments, which should be more tolerable for patients for this affective mood disorder, this could include improving existing drug treatments. Although Bipolar is one of the oldest known mental illness it was never classified; the symptoms were described and examined throughout history and sometimes the etiologies which were established were imprudent. Mania was seen as occurring from an excess of yellow bile, or a mixture of black and yellow bile. The theory of a link between mania and depression goes back to the 2nd century AD. Soranus of Ephedrus (98-177 AD) described mania and depression as diseases with different etiologies; however, he acknowledged that many others consider melancholia a form of the disease of mania. Depression was formally known as melancholia. In 1650, a scientist named Richard Burton determined the characteristics of depression in The Anatomy of Melancholia. His findings are still used today in the mental health field, and he is established as being the father of the study of depression.Emil Kraepelin (1856-1926), a German psychiatrist first termed the disease as manic depressive psychosis. He stud ied the disorder in untreated patients. In 1948, Dr. Cade a psychiatrist found out that Lithium Carbonate could be used as a successful treatment of manic depressive disorder. This was the first time a drug had been discovered that proved to be a successful treatment of this condition. The current term bipolar disorder replaced manic depressive disorder in 1980, and featured as diagnostic term in the Diagnostic and Statistical Manual of the American Psychiatric Association (DSM-III).Most diagnosis of bipolar disorder are based on DSM IV (2000). Due to the complexity of brain function, the aetiology and pathophysiology of the disorder is not very well understood .The debate as to whether it is genetic factors or neurobiological factors which contribute to bipolar disorder is ongoing. Genetics have been known to play a major role in aetiology of bipolar disorder from early on, however many theories suggest neurotransmitter dysfunctions in depression, and therefore maybe the best explanation to finding the cause of Bipolar disorder would be to investigate a chemical basis of the disorder, as this review will examine. The pathophsysiolgy has recently been overtaking research on genetics of bipolar disorder. It would be essential to study the same neurotransmitters which have implicated in cause of depression and the areas affected by medications which alleviate symptoms of manic-depression (Ackenheil, 2001). Theories about neurotransmitter abnormalities in bipolar disorder have been created by experiments which have been created by experiments studying the effects of pharmacological treatments. Lithium was first used 40 years ago to treat bipolar disorder, studies on the effects of lithium, its target and mechanism of action on bipolar patients have indicated mostly monoamine neurotransmitter abnormalities are involved behind bipolar disorder however even though large amounts of research on neurotransmitter abnormalities have been conducted the aetiology of bipolar is far from completely understood. Many patient are unaffected by lithium, this shows that bipolar disorder may have more than one cause maybe this accounts for the various symptoms involved in this disorder. Many models focus on one neurotransmitter or neurotransmitter system as the case of bipolar disorder however these models cannot be sufficient enough to explain the array of symptoms. A valid general theory has to consider opposite effects of activity of neurons leading to the cycle of mood states, this could be a system involving the releases of transmitters, abnormality in cerebral activities or a regulatory protein involved in the interaction of various systems on levels of signal transduction. The debate above provides the basis for this review. To understand the neurochemistry of bipolar disorder the molecular and cellular systems have to be determined. This literature review is organized around the signal transduction pathways and central neurotransmitter systems and convergence of these areas to provide an insight into the pathophysiology of bipolar disorder. Neurotransmitters involved in this review are serotonin, dopamine and noradrenalin. The neuroamine exert their action through postsynaptic receptors which are coupled to Guanine nucleotide binding proteins (G proteins). This is the main part of the intracellular signalling mentioned in this review. Other systems which have also been studied are sodium and calcium transport, disturbances in these systems have been implicated in the physiology of bipolar disorder, although this topic is beyond the scope of this review and there is relatively little research compared to G coupled proteins and cyclic AMP system, Given this, and the authors own personal interests, it was decided to focus on G coupled proteins and cyclic AMP system and the other main pathway phosphoinositide. 3. Aims This literature review aims to provide a critical evaluation of the research investigating the structures and circuits involved in the aetiology of bipolar affective disorder. Initially neurotransmitters and signal transduction will be examined and outlined by introducing the most popular and widely-used theories associated with the development of bipolar disorder and explain by what is meant by bipolar. Following this a search protocol is included: an explanation of how the reviewed articles were sourced and analysed. After which will follow a comprehensive review of the studies found in the search about how each neurotransmitter and signal transduction affect bipolar disorder. Also the disagreements and contradictions in the literature will be discussed. The implications and limitations of these findings of the studies found will then be considered and topics for future research presented. 4. Bipolar Affective Disorder 4.1. Diagnostic Criteria There are two types of bipolar disorder; Bipolar I and Bipolar II. Bipolar II consist of symptoms which are not as severe or prolonged as Bipolar I. The criteria for bipolar disorder is complex and is separated into six criteria sets theses are: single manic episode, most recent episode hypomania, most recent episode depressed, most recent episode mixed, most recent episode depressed and most recent episode unspecified. The table below summarizes the main DSM-IV classification (4th edition) criteria for the diagnosis of bipolar I and bipolar II disorder. Table 1 DSM-IV category Criteria Bipolar I Presence of one or more manic or mixed episodes, current or most recent episode: accompanied by one or more depressive episodes .Severe: with psychotic features In partial or full remission: With catatonic features With postpartum onset Current or most recent major depressive episode: significant distress occurs. Depressive state occurs more frequently then mania. Bipolar II No history of manic episode, not as severe as Bipolar I. Characterised by at least one hypomanic episode and depressive episode 4.2. Major depression Depression can distort an individuals way of thinking about themselves, their lives and of other people around them. Individuals who are diagnosed with depression tend to have higher negative views and fail to see the positive in any situation. Depression can also occur as anger. If episodes of low or depressed mood and a decrease in energy, activity, interest, or pleasure occur for two weeks the individual is diagnosed as major depressive ( DSM IV, 2000) 4.3. Mania Mania is the abnormal elevation of emotions, usually occurrence of irritable mood, inflated self esteem and may feature delusions or hallucinations (psychotic symptoms) when symptoms are less severe the patient is experiencing a hypomania episode. Mania can manifest itself in many forms. The DSM-IV splits the severity of mania symptoms into further subgroup for accurate diagnosis: Mild: symptoms barely meet criteria for an episode of mania. Moderate: There is a high increase in either activity level or impaired judgment. Severe without psychotic features: The patient requires continuous supervision to prevent physical harm to self or to others. Severe with psychotic features: The patient has delusions or hallucinations which may be mood-congruent or mood-incongruent. The table below summarises the symptoms of mania and depression Table 2 Mania Depression Need for sleep is decreased Increased talkativeness, pressure to keep talking, hyperactiveness Flight of ideas may be erratic- raving thoughts Incomprehensible speech Excess involvement in pleasurable activities e.g. impulsive sex- potential for painful consequence Having unrealistic beliefs in abilities Increasingly involved in goal relative activities, starting new projects Feeling constantly tired Having problems concentrating, remembering, and making decisions Lack of pleasure in activities Negative thoughts Being restless or irritable Changing eating, sleeping, or other habits (excess sleep usually occurs) Contemplating death or suicide, or attempting suicide. An individual with hypomanic episodes may have increased energy although the symptoms are not as severe as typical mania, the symptoms may come in episodes that last less than a week, do not require hospitalisation and will not be classified as full blown bipolar disorder I. A person having a hypo manic episode may feel they are on a high, be extremely productive, and function well. The individual may not perceive their behaviour as abnormal although these mood swings may be apparent to friends and family members. Without treatment, however, individuals with hypomania may develop severe mania or depression. 4.4. Definition issues Very few patients with bipolar alternate between episodes with pure mania or pure depression, many however have a variety of patterns and are regularly in a mixed state and rapid cycling between mania and depression occurs. Some experience months of depression followed by months of mania, some can swing states in a matter of hours (Berk et al 2005) this is usually defined as bipolar spectrum and can complicate diagnosis. There are unclear boundaries which can limit the selection of appropriate treatment. Accurate diagnosis on basis of clinical interviews may not be possible as many patients at the time of interview are in one phase. The psychotic symptoms reflect the persons extreme mood. For example, if a person is having a manic episode he/she may experience psychotic symptoms such as believing he or she is famous, has a lot of money, or has special powers which may make them invincible , this can be quite dangerous and can lead to death( Bauer, Michael et al, 2002). On the other h and, a person experiencing a depressive episode may believe he or she is ruined and penniless, or has committed a crime which in turn can lead to suicide. Due to these psychotic symptoms in individuals with bipolar disorder are sometimes wrongly diagnosed as having schizophrenia, another severe mental illness that is associated with hallucinations and delusions. People with bipolar disorder may also have other behavioural problems. Many turn to alcohol or substances, others tend to have attention deficit hyperactivity disorder (ADHD) or post traumatic stress disorder (Strakowski S.M. et al, 1998) so initially its not easy to recognize these problems as signs of a major mental illness. Individuals with Bipolar disorder sometimes go through states where they exhibit minimal symptoms however they still have the vulnerability for mood deregulation, this state is called euthymia (Strakowski et al.2004). There are no separate criteria for diagnosis of children although it has been stated that bipolar disorder in children is slightly different from bipolar in adults. 4.5. Treatment The treatment for Bipolar I Disorder is usually lifelong therapy with a mood-stabilizer this can be Lithium, Carbamazepine, or Divalproex / Valproic acid often in combination with an antipsychotic medication. Many of these medications are anticonvulsants except for lithium. Anticonvulsants medications help control moods although are usually used to control seizures. An antipsychotic medication and/or a benzodiazepine medication are often added to the mood-stabilizer in mania. In depression, Quetiapine, Olanzapine, or Lamotrigine is frequently taken with the mood-stabilizer. Alternations occur between medications, in depression, the mood-stabilizer is sometimes substituted for another mood-stabilizer, or in some cases two mood-stabilizers can be used together. Occasionally, antidepressant medication is used in depression. However as antidepressant medication can trigger mania, antidepressant medication is always taken in combination with a mood-stabilizer or antipsychotic medication t o prevent mania (Ackenheil, 2001). Research has shown that the most effective treatment for bipolar disorder is a combination of supportive psychotherapy, and the use of a mood-stabilizer and antipsychotic medication (Miklowitz D.J. 2006) 5. Monoaminergic Neurotransmitter systems 5.1. Serotonergic system Serotonin pathways originate in the raphe nuclei and project throughout the cerebral cortex. Serotonin is known to interact with the other neurotransmitters, it modulates different neuronal activities, Serotonin triggers sleep wake cycles, mood and emotional behaviour; deficiency can lead to migraines (Birkmeyer, W. and P. Riederer, 1989) this neurotransmitter increases the threshold for pain, reduces arousal functions, hyperactivity results in improved appetite, weight increase, an increased urge to sleep, lowered consciousness, slower thought processes, and lack of drive, most of which have been shown to be symptoms of depression in bipolar disorder. Serotonergic cell bodies originate mainly in the upper Pons and the midbrain-specifically, the median and Dorsal raphe nuclei, the Candal locus ceruleus, the Postrema area, and the inter peduncular area. These neurons project to the basal ganglia, the limbic system, and the cerebral cortex. (Kaplan et al. 1994). 5.2. Noradrenergic system The Noradrenalin (NA) system originates in the locus coeruleus, lateral tegmental area in the brain stem and projects diffusely through axonal pathways to the cortex, amygdale and hippocampus, in the CNS it is involved in a wide range of neurological and psychological functions, which include cognition, attention, emotion, and memory formation (Robbins and Everitt 1995, Moore and Card 1984). Activation of NA neurons increases cellular responsiveness to sensory information as inhibition of the background activity of the target neurons occurs and also increases the selectivity of the responses to relevant stimuli (Foote et al 1983). NA is also involved in the fight or flight reaction. NA changes the efficiency of the excitatory and inhibitory synaptic transmission in particular neurons although it is dependent on the subtypes of adrenergic receptor (AR) and secondary messengers (Dohlman Et al 1991). 5.3 Dopamingenic system There are eight major dopaminergic pathways in the brain. The three main pathways originate from the midbrain, they are as follow: Mesolimbic pathway-consists of a bundle of dopaminergic fibres which are associated with the reward circuit. This pathway develops from the ventral tegmental area and innervates various formations of the limbic system, which include the nucleus accumbens. The mesolimbic pathway is involved in memory and is important for motivating behaviours. Mesocortical pathway also originates in the ventral tegmental area, although also projects to the frontal cortex and surrounding areas. Dysfunction in this pathway might be the cause of some of the symptoms such as hallucinations and disordered thinking in bipolar disorder. Medications used to reduce psychotic delirium block this pathway, and also reduce the overall activity of the frontal lobes. Tuberoinfundibular pathway- is located in the hypothalamus and releases dopamine into the portal vessels thus regulating the functioning of the pituitary. These distributed pathways are responsible for behavioural areas such as impulsivity and attention, reward seeking, emotional processing, working memory, and other executive functions. The actions of the neurotransmitter dopamine are usually connected through G-protein-coupled receptor slow transmission, which in turn modulates fast neurotransmission in glutaminergic and GABA- ergic neurones. There are two types of dopamine receptors D1-type and D2-type. D1-type receptors (D1 and D5) are mostly coupled to Gas and then stimulate the production of the second messenger cyclic-AMP (cAMP), whereas D2-type receptors (D2, D3, and D4 included) are coupled to Gai à ¢Ã‚ Ã¢â‚¬Å¾ o and decrease the production of cAMP and related downstream pathway. The various types of dopamine receptors are diffused throughout different areas of the brain (Greengard P. 2001) 6. Signalling transduction 6.1. G- Coupled proteins and Cyclic AMP system G-proteins are an important component of the intracellular signalling pathway; they interlink receptors in the membrane to the different intracellular effecter molecules which in turn produces responses. G-proteins are made up of 3 sub units: an a subunit which binds and hydrolyzes guanosine triphosphate (GTP) these can be further divided into subunits of Gas, Ga, Gaq, Gao and b and g subunits which are firmly bound to one another. Various combinations of protein structures can be established out of these subunits thus creating a number of receptors for different or similar signal transduction systems. Small changes in the subunits of the G proteins can highly alter the order of events in signalling from receptors to the intracellular targets (Birnbaumer L, 1992, Spiegel et al., 1992) These G-protein coupled receptors stimulate or inhibit mainly two second messenger systems: cAMP and Phosphoinositol After receptor activation, G-proteins connect to various effectors (enzymes). This pathway involves coupling of G protein (inhibitory or stimulatory) sub units to enzymes for example adenyl cyclase (AC). Different forms of the enzyme AC catalyze to produce cAMP this is via adenosine triphosphate (ATP).cAMP controls cellular functions such as metabolism and gene transcription.As cAMP degrades quite quickly in the brain by phosphodiesterase binding of cAMP to another enzyme cAMP-dependent protein kinase (as protein kinase A) is used as an indirect measurement of cAMP. This enzyme is critical for connecting any short term changes in neurotransmitter signalling to long term neurobiological changes (Beavo J.A, 1974, Scott JD, 1991). 6.2. Phosphoinositide (PI) Pathway Another signalling path way involved in the coupling of neurotransmitter receptors is phosphoinositide , this pathway involves the phosphatidylinositol-specific phospholipase (PLC) enzyme, and the G-protein subtypes Gq/G11, (Perez et al ,2000) Hydrolization of inositol-containing phospholipid phosphatidylinositol 4, 5-bisphosphate (PIP2) to two important second messengers: 1, 2-diacylglycerol (DAG) and inositol 1,4,5-triphosphate (IP3) is induced by the activation of the receptors which stimulate PLC (Smrcka et al 1991). Inositol monophosphate (IP) is made by conversion of IP3. IP is then again converted into inositol which is then available for resynthesis of PI. Lithium decreases the level of inositol in the brain, it blocks the conversion of IP to inositol by interfering with inositol monophosphate phosphatise conversion of IP to inositol. 7. Theories There have been a number of theories of depression and mania separately. The main neurotransmitter system implicated in the development of bipolar disorder is the serotonin system and is still the most widely studied system; however there is evidence suggesting that other neurotransmitter systems also play important roles (Barros et al. 2002). The biogenic amine theory of depression (Bunney and Davis 1965; Schildkraut 1965) is based upon a link between pharmacological alterations (medications taken by Bipolar patients) of monoamines and modulation of affective disorders. Decreasing amine neurotransmitters (noradrenalin (NA) and serotonin (5-HT) in the synaptic clefts) leads to an increased incidence of bipolar affective disorder. Another theory suggests that antidepressants alter the concentration of neurotrophic factors which are essential for neuronal survival (Duman et al, 1997; Duman, 2002). Although recently it has been suggested that instead of being a simple case of depletion in some crucial cerebral transmitter; concentrations depression may be the result of a disturbed balance between various regulatory systems, which may lead to transmitter over activity in some brain regions (Syvà ¤lahti 1994). Another hypothesis by Harro Oreland (1996) the neurobiological aetiology of depression may lie in the alteration of the noradrenergic innervations from the locus coeruleus, which, in turn, may lead to dysfunction of serotonergic and dopaminergic neurotransmission. Theories associated with the Multicomponent, cellular signalling pathways suggest that the interaction at various levels is important, which form complex signaling networks essentially allowing the cell to obtain, process, and respond to information (Bourne HR, Nicoll R,1993, Weng G et al, 1999). The cascades of signals are assisted by these networks in a matter of milliseconds, they are crucial for physiological processes as they can alter the strength and duration of outputs and feedback. Thus abnormalities in these pathways may have variety of affects in different neurological disorders (Bhalla U.S. 1999). Patients treated with antidepressants have increased activation of cAMP system in particular regions of the brain. This causes the high expression rate of the transcription factors that are involved in this system (cAMP response element binding protein- CREB) which leads to the increased expression of neutrophic factors in hippocampus and cerebral cortex neurons theses neurotrophic factors are essential for survival and functioning of certain neurons these studies have lead to the molecular and cellular theory of depression. 8.Method 8.1. Search protocol A breakdown of how the search was conducted is presented in Figure 1 below: Less detail Level of detail in search more detail Start Time of search finish Keywords Bp = Bipolar Disorder S= Serotonin D= Dopamine N= Neurotransmitter ST= Signal Transduction NA= neuroadrelaline GP= G proteins PI= Phosphoinositide cAMP= cAMP pathway 8.2. Selection method Articles were searched on several journal databases these included web of knowledge, Science Direct and Medline. Key words were chosen to assist with the search. Key words included: signal transduction, neurotransmitters, bipolar disorder, mania, serotonin, dopamine, noradrenalin and depression. Articles were selected by at first by reading the abstract and deciding whether the article was directly answering or related to the review question. If this link was established, the article was considered as having passed the first stage of screening Once all databases had been searched for those articles that passed stage one screening, further analysis was carried out. Articles werent excluded on basis of country of origin or date of publishing. Many studies incorporated different factors for example 8.3. Articles excluded Certain articles which were found within the search protocol were not included in this literature review. There is a large amount of literature investigating the genetic links to neurotransmitter receptors and bipolar disorder that purely focused on this factor although articles that purely focused on this factor were not included in the review. 9. Findings Direct and indirect methods which have been used in the studies include: brain studies, CSF studies, platelet studies and psychopharmacological have all been included in this review as it is difficult, to measure the chemical and physiological activity within the brain in vivo. Peripheral lymphocytes share many common characteristics with neuronal cells thus considered suitable models for testing various hypothesises. Lymphocytes have various neurotransmitter receptors on their cell membrane 9.1.Neurotransmitter studies Noradrenergic system has been shown to be involved in the pathophysiology of bipolar disorder. In depressive states, noradrenergic system has under functioned these results from these studies are taken from indirect measurements of noradrenalin metabolism in body fluids. Measuring desmthylimipramine, the growth hormone secretion shows estimate activity of noradrenergic neurons in the brain (Laakmann et al 1990). Abnormalities in the level of noradrenalin in plasma of patients has been observed which support the hypothesis that this neurotransmitter is involved in the aetiology of bipolar disorder , in subjects with mania the concentrations of NA has been increased ( Manji, Lenox, 2000) also the metabolite of noradrenalin (-methoxy-4-hydroxyphenylglycol -MHPG) has been established to be higher concentration in the urinary and cerebrospinal fluid of mania state than in depressive state ( Goodwin et al, 1990, Bowden CC 1997, Schatzberg AF et al 1995, Manji et al 1997). These were all longitudinal studies and therefore had higher validity compared to studies only examining one state of mood in bipolar disorder. Higher values were also noted in unipolar depression compared to bipolar depression (Goodwin FR, Jamison KR 1990, Manji et al 2000). Lower noradrenalin output and altered sensitivity of a2 receptor activity have been discovered in depressive states this has been indicated by the lowered growth hormone response to clonindine leading to a decrease in noradrenalin activity compared to in maniac state where noradrenalin release is increased (Delgado, 2000; Manji Lenox, 2000). Increased levels of a2 receptors in the hypothalamus, amygdale, hippocampus and cerebellum have also been reported (Delgado 2000, Young et al 1994, Vawter M.P et al 2000,). Another group of studies on serotonin and serotonin metabolism have shown that a lower concentration of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) was found in bipolar disorder patients, particularly in aggressive bipolar patients and those who have attempted or contemplated suicide but were raised in patients with mania (Manji Lenox, 2000, Traskman et al 1981, Swann et al 1983, Asberg et al, 1984). Smaller numbers of serotonin uptake sites were also found in post mortem brains of depressed individuals with bipolar disorder ( Leake et al, 1991) other drug studies on Tryptophan, an essential amino acid on which serotonin synthesis is dependent on have established that prescribing tryptophan to patients with depression may sometimes result in the reversal of the therapeutic effect of selective serotonin re-uptake inhibitor administration and depression may reoccur, this suggests that serotonin levels in brains of bipolar disorder patients may not be the only cause of this disorder. Extensive results from CSF experiments, serotonin receptor and re uptake site binding studies, pharmacologic studies have been achieved which support the theory that alterations of serotonergic neurotransmission in depressive states occur (Goodwin et al 1990, Maes et al 1995, Garlow et al 1999). In studies of CSF 5-HIAA in patients with bipolar disorder in mania episode has generally produced inconsistent and conflicting results (Goodwin 1990, Shiah et al 2000). Most studies found no difference in levels of CSF 5-HIAA levels between depressed state and manic state, two reported both manic and depressive states have lowered CSF 5-HIAA levels and one reported manic have significantly lowered levels of CSF 5-HIAA compared to control subjects. More research in this area needs to be conducted in order to achieve consistent results (Goodwin, 1990). Maes et al (1995) and Garlow et al (1999) researches found decreased concentration of radioligand binding to the serotonin transporter which is involved in taking up serotonin from the synaptic cleft. These results were found both in platelets and mid brain of depressed subjects. Positron emission tomography (PET) studies have also reported decreases in 5-hydroxytryptamine (5- HT)1A receptor binding potential in the raphe and hippocampus and amygdala of the brains of depressed patients, especially in patients with bipolar and in unipolar patients with history of bipolar in their family, indicating a genetic link ( Drevets, 1999) To produce a more direct measurement of serotonergic system function neurotransmitter depletion models are used in the case of bipolar disorder tryptophan depletion to lower serotonin levels is used. Serotonin synthesis is dependent on Tryptophan, an essential amino acid. Depletion of tryptophan is created by the Australia: Inflation, Balance of Payment and Monetary Policy Australia: Inflation, Balance of Payment and Monetary Policy What is the main measure of inflation movements in Australia and what does it represent? CPI refers to the Consumer Price Index and is used as the primary measure of inflation movements within Australia over time. CPI can be defined as a measure of how the prices of goods and services change over time. It is a measure of overall cost a typical consumer pays for the purchase of goods and services. A larger increase in CPI represents an inflationary trend in the economy and decrease in CPI shows deflationary situation. It also helps in comparing the inflation patterns with other countries of the world. CPI can be calculated using the following formula: Inflation refers to the persistent rise in the general price level in the economy. Rising inflation negatively affects the purchasing power of a typical consumer, therefore, a typical family has to spend more to maintain his existing standard of living. We can estimate the rate of inflation in the following way: Where: refers to Inflation rate in the current financial year. refers to CPI in the preceding financial year. refers to CPI in the current financial year. CPI is considered as a benchmark inflation guide for the Australian economy The balance of payment is a record of monetary transactions between Australia and the rest of the world- it is made up of two accounts. What are the names of the accounts and what do they measure? Balance of payment keeps track of inflow and outflow of money from the economy of a country. It consist of two main accounts:- Current Account Capital Account Current Account The current account measures trade flow in and out of the country. In other words, it represents country’s exports and imports. It consist of following three components. Trade in goods and services Net Foreign Income Current Tranfer/Foreign aid Trade in Goods and Services The most important component of the current accounts is the balance of trade showing the country’s imports and exports of goods and services. If exports are larger than imports, it is a balance of trade surplus and if exports are fewer than imports shows a balance of trade deficit. Net foreign Income If local companies or individuals of a country (let say Australia) purchase bonds and stocks in other countries, the money will come into the country in the form of interest and dividend payments and will add to the net foreign income. On the other hand, the money that leaves the country in the form of interest payments and dividends to foreign investors, royalties paid by the subsidiaries (located in Australia) to their overseas head offices decreases the total net foreign income. Current transfer / Foreign Aid Grants/ donation and workers (foreigners) send money to their home countries. Current Account Surplus and Deficit Current account surplus means that country is earning more than spending or in other incoming money (credits) exceeds outgoing money (debit). It means the country has more money to lend to other countries. Whereas, the current account deficit shows that the spendings of a country are higher than income/earnings. Capital Account It tracks the movements of funds for investment into and out of the country the capital account consist of four main components such as: Direct investment: Portfolio Investment Government Capital Official Reserve Direct investment: It refers to the foreign direct investment when the investor acquires ownership and control over these assets. Portfolio Investment It represents money that flows into and out of the country for the purchase of financial assets like stocks and bonds, whereas, the payment of the dividends and interest from these foreign investments will be the part of the current account and will not be counted towards capital account. Government Capital It refers to the Government borrowing from and repayments to overseas countries. Official Reserve The net foreign exchange transactions of central banks. Capital Account Surplus and Deficit The capital account surplus means more inflow of foreign capital into the country in the form of investments and the capital account deficit shows outflow of foreign capital from the country for investments compared to the domestic investment. A capital account surplus is usually being balanced by the current account deficit and vice versa. Together, these accounts constitute Balance of Payment (BOP), because of their offsetting nature the complete understanding of these two accounts is crucial for traders. How does the Reserve Bank of Australia, Institute monetary policy? Reserve Bank of Australia (RBA) was constituted under the Reserve Bank Act 1959, and is responsible for preparation and carrying out of monetary policy. By definition monetary policy has been a process by which the monetary authority holds the provision of money, often targeting interest rates to achieve economic targets of low inflation and long term growth stability. Objectives of Monetary policy In setting monetary policy RBA is responsible to maintain the pursuit: Stability of Australian currency Full Employment Economic Prosperity and welfare of the people of Australia. In order to achieve above mentioned objectives, the Reserve Bank of Australia sets a targeted official cash rate (interbank overnight rate). The cash rate adjustments influence the other interest rate in the economy, expectations of community, exchange rate and ultimately involve the pace of rising prices (inflation rate). The appropriate target inflation rate agreed by RBA and Govt is at 2 to 3 percent on average over the cycle, as this rate will not materially affect the spending and investment patterns in the economy. As monetary policy is a means of influencing the economy by controlling the supply of money. By Act of Parliament RBA can manage the quantity of circulation of money through changing cash rate, buying and selling Govt securities and by making changes to statutory reserve deposits. The RBA usually meets once in every month, examine the health of the economic system as a whole and by reviewing the checklist of different economic indicators both domestic and international to decide on their monetary policy. Any decision/changes needed at the conclusion of the meeting, then communicated publicly. There are two types of monetary policies which are as follows: Expansionary monetary policy: It stimulates production and employment through an increase in the supply of money on credit in the market. The RBA can implement this policy by decreasing the cash rate or lowering reserve requirements in order to promote borrowing and spending in the economy. Small businesses often benefit with the execution of the expansionary monetary policy, but it has some drawbacks like decrease in value of currency, raise in inflation, output shortage, higher demands of wage etc. The objective of the RBA is to balance the available money to interest rate in order to ensure expansionary effect on the economic system. Contractionary Monetary policy: The primary aim of this type of policy is to draw out money out of the economic system to prevent the rising prices, decrease consumer spending and increase the value of currency. The activities through which RBA tightens monetary policy includes decreasing the official cash rate or by increasing the reserve requirements from other banks make it harder for consumers and investors to borrow money and persuade them not to drop more money. A monetary contraction further stabilize the prices of goods as inflation goes down. This policy slows down production because there is reduce demand for their products. An investor can also plan to cease planned expansion and this may cause unemployment in the future. What are the implications of rising or high inflation? In simple language inflation means an overall increase in prices of goods and services in the economy or decrease in the purchasing power of money over time. Inflation is caused by an increase in demand for commodities and services strongly outweighs the supply of commodities and services in the economy. Inflation rate can easily be calculated on monthly or yearly basis by applying the CPI. Inflation rate in Australia as reported by the Australian Bureau of Statistic is 2.9% in the first three months of 2014, up from 2.7 percent in the previous quarter but still it is below market forecasts. This cost increase was primarily due to seasonal increases in the cost of health care, school fees, transport and by large increases in tobacco duties. Impact of High Inflation on the Economy: High inflation is harmful to the economy as it moves in many ways such as: Distort Consumer Behavior: Consumer purchases their future required goods in advance because of the fear of price increase this can create a sudden shortage of goods in the market. Higher Wage Demands: Prices increase lead to higher wage demand as the fixed income earners require more money to keep their previous living standard. This process is called wage-price spiral. Greater Uncertainity: During inflation, rapid fluctuation in inflation rate can undermine business confidence. As it makes difficult for business organizations to accurately determine prices for their products and their returns from investment i.e. budgeting and investment valuation become difficult Firms may postpone their investment expansion because of lower consumer spending and this will adversely affect the economic growth in the economy. Savings Decrease: At high inflation times, people spend more money to keep their previous living standard therefore least amount they keep. As savings in the economy decrease less loanable funds are available for the firms to invest. Unemployment Rise: When the firms decide to curtail their current production or lay off their planned expansions they will not hire more workers this leads to lower job opportunities available in the economy. Damage to Export Competitiveness: Due to high inflation, the production cost of goods rise and their export will become less competitive in the international marketplace. This has an adverse result on the Balance of payments. Social Unrest: High inflation lead to a general feeling of discomfort for households as their purchasing power is falling and they have to postpone many of their desires. Hoarding in Economy Increase: Rapid increase in prices can sometime result in hoarding of basic commodities to gain more profit margins. What is the main economic indicator of growth in the economy? Economic indicator shows in which the direction of the economy is going. There are three primary types of economic Indicators i.e Leading, Coincident and Lagging indicators. In monitoring the economic growth and health, Govt, reserve bank (RBA) and other economist not only observe one indicator, simply stick with a large no domestic and of key economic indicators like inflation, GDP, inflation, Employment, wages, consumer an international d investment spending, interest rate, Balance of payment, Exchange rate etc. But the most comprehensive measure of economic performance is GDP (Gross Domestic Product). It is the best measure as it includes the output of all sectors and gives overall performance of the economy. It is likewise applied to evaluate the quality and success of Govt policy to attempt to attain the target economic growth. GDP by definition is the total value of all final goods and services produced in a country within a year. There are two methods normally applied to calculate GDP: Expenditure Approach Income Approach Expenditure Approach:- The total amounts spent on the goods a and services produced in a nation by households, firms, Govt and foreigners. Households consumptions (C) include all spending for the consumption of goods and services, business firms also consumes product in the form of investment (I) in capital goods. Capital goods means the tools and technology firms purchase to use in the production. Govt also consume products in the form of infrastructure goods (roads, bridges), services like education (public schools), health care (old age/poor persons medical coverage). Foreigners when purchase our nations goods (X) it increase GDP in the form of and when our other nation purchase other countries (M) products it decreases nations GDP. The formula to calculate GDP by expenditure Approach:- GDP = C + I + G + ( X – M ) Income Approach In an economy in different ways, such as rentals (Land), Wages depending on skilled /unskilled Capital income (Interest income from their savings at banks or other savings institutions) and in of profits from managing their own businesses (Enterpreurship). If we add all these types of incomes, we get the total of the nations income. The formula to calculate GDP by income approach is given below. GDP = Rentals (R) + Wages (W) + Interest (I) + Profits (P) For the economy as a whole total Income is equal to total expenditure because every dollar spend by a buyer is a dollar income for a seller. The limitations of using GDP as economic indicator:- GDP does not count for volunteer work which people do freely. People work freely in schools, hospitals etc.. GDP didnt include the effect of rebuilding after a natural disaster or war. Rebuilding increase the GDP. GDP does not consider the quality of goods. The consumer may go for cheap/low quality goods instead of expensive one this may lead to repetitive buying as of low quality aspect. More buying pattern affects the affect the GDP. Nevertheless despite of its few limitations economist uses GDP as to assess whether the purchasing ability of the nation increase / decline in the economy and also to quantify the relative growth, wealth and prosperity of different countries.

Othello †How it Ranks Essay -- Othello essays

Othello – How it Ranks  Ã‚         In the context of thousands of plays written by hundreds of dramatists since 500 years prior to the time of Christ, how does William Shakespeare’s play Othello rank? In this essay let us find the proper place for this play, and consider critical opinion in the process.    Othello would appear to have a beauty about it which is hard to match – thus ranking high. Helen Gardner in â€Å"Othello: A Tragedy of Beauty and Fortune† touches on this beauty which enables this play to stand above the other tragedies of the Bard:    Among the tragedies of Shakespeare Othello is supreme in one quality: beauty. Much of its poetry, in imagery, perfection of phrase, and steadiness of rhythm, soaring yet firm, enchants the sensuous imagination. This kind of beauty Othello shares with Romeo and Juliet and Antony and Cleopatra; it is a corollary of the theme which it shares with them. But Othello is also remarkable for another kind of beauty. Except for the trivial scene with the clown, all is immediately relevant to the central issue; no scene requires critical justification. The play has a rare intellectual beauty, satisfying the desire of the imagination for order and harmony between the parts and the whole. Finally, the play has intense moral beauty. It makes an immediate appeal to the moral imagination, in its presentation in the figure of Desdemona of a love which does not alter ‘when it alteration finds’, but ‘bears it out even to the edge of doom’. (139)    The play is so quotable; consider Desdemona’s opening lines before the Council of Venice: â€Å"My noble father, / I do perceive here a divided duty,† or Othello’s last words: â€Å"Killing myself, to die upon a kiss.† Could the continuing reputat... .... San Diego: Greenhaven Press, 1996. Reprint from â€Å"The Noble Moor.† British Academy Lectures, no. 9, 1955.    Heilman, Robert B. â€Å"The Role We Give Shakespeare.† Essays on Shakespeare. Ed. Gerald Chapman. Princeton, NJ: Princeton University Press, 1965.    Levin, Harry. General Introduction. The Riverside Shakespeare. Ed. G. Blakemore Evans. Boston: Houghton Mifflin Co., 1974.    Shakespeare, William. Othello. In The Electric Shakespeare. Princeton University. 1996. http://www.eiu.edu/~multilit/studyabroad/othello/othello_all.html No line nos.    Wright, Louis B. and Virginia A. LaMar. â€Å"The Engaging Qualities of Othello.† Readings on The Tragedies. Ed. Clarice Swisher. San Diego: Greenhaven Press, 1996. Reprint from Introduction to The Tragedy of Othello, the Moor of Venice by William Shakespeare. N. p.: Simon and Schuster, Inc., 1957.    Othello – How it Ranks Essay -- Othello essays Othello – How it Ranks  Ã‚         In the context of thousands of plays written by hundreds of dramatists since 500 years prior to the time of Christ, how does William Shakespeare’s play Othello rank? In this essay let us find the proper place for this play, and consider critical opinion in the process.    Othello would appear to have a beauty about it which is hard to match – thus ranking high. Helen Gardner in â€Å"Othello: A Tragedy of Beauty and Fortune† touches on this beauty which enables this play to stand above the other tragedies of the Bard:    Among the tragedies of Shakespeare Othello is supreme in one quality: beauty. Much of its poetry, in imagery, perfection of phrase, and steadiness of rhythm, soaring yet firm, enchants the sensuous imagination. This kind of beauty Othello shares with Romeo and Juliet and Antony and Cleopatra; it is a corollary of the theme which it shares with them. But Othello is also remarkable for another kind of beauty. Except for the trivial scene with the clown, all is immediately relevant to the central issue; no scene requires critical justification. The play has a rare intellectual beauty, satisfying the desire of the imagination for order and harmony between the parts and the whole. Finally, the play has intense moral beauty. It makes an immediate appeal to the moral imagination, in its presentation in the figure of Desdemona of a love which does not alter ‘when it alteration finds’, but ‘bears it out even to the edge of doom’. (139)    The play is so quotable; consider Desdemona’s opening lines before the Council of Venice: â€Å"My noble father, / I do perceive here a divided duty,† or Othello’s last words: â€Å"Killing myself, to die upon a kiss.† Could the continuing reputat... .... San Diego: Greenhaven Press, 1996. Reprint from â€Å"The Noble Moor.† British Academy Lectures, no. 9, 1955.    Heilman, Robert B. â€Å"The Role We Give Shakespeare.† Essays on Shakespeare. Ed. Gerald Chapman. Princeton, NJ: Princeton University Press, 1965.    Levin, Harry. General Introduction. The Riverside Shakespeare. Ed. G. Blakemore Evans. Boston: Houghton Mifflin Co., 1974.    Shakespeare, William. Othello. In The Electric Shakespeare. Princeton University. 1996. http://www.eiu.edu/~multilit/studyabroad/othello/othello_all.html No line nos.    Wright, Louis B. and Virginia A. LaMar. â€Å"The Engaging Qualities of Othello.† Readings on The Tragedies. Ed. Clarice Swisher. San Diego: Greenhaven Press, 1996. Reprint from Introduction to The Tragedy of Othello, the Moor of Venice by William Shakespeare. N. p.: Simon and Schuster, Inc., 1957.   

A Struggle for Acceptance of Gays Essay -- Homosexuality Religion Marr

A Struggle for Acceptance of Gays "When the dust settles and the pages of history are written, it will not be the angry defenders of intolerance who have made the difference, that reward will go to those who dared to step outside the safety of their privacy in order to expose and rout the prevailing prejudice." - John Shelby Spong Episcopal Bishop of the Diocese of Newark, NJ November 21, 1996 During World War II and especially the twenty years after brought great political and social changes to the U.S.. Undoubtedly, one of the major changes was the new awareness of homosexuality. If this new awareness was to the advantage or if it was really wanted by the gay and lesbian population is a question that arises; if they really had a choice in the matter is another. I think gays' relentless struggle for acceptance into mainstream society came from the American constitution itself. After all, the gay liberation movement started in America, the land of the free, where all men are created equal and with an inalienable right to pursue their own happiness. No one should be able to take these rights away from anyone. Also, in the 1950s, the civil rights movement became active and words like desegregation and equal rights for all became synonymous with the American way of life. Stand up and fight against those who have done you wrong! This is what gave homosexuals such a conviction to start fighting for their own cause. This paper will follow the progress of gay and lesbians in the twentieth century before, during and after World War II. What was their position in the armed forces during the war and what was government and military policy during and after the war on gays in the army and in government positions? How did gay and lesbians respond to the new policies after the war and why were organizations like the Mattachine Society and the Daughters of Bilitis founded? On December 7, 1941 at 7:55 a.m. local time, Japan attacked Pearl Harbor. The Unites States declared war on Japan and was suddenly a participant in the largest war in the history of mankind. A massive military force of 12 million men was assembled. American soldiers were sent to Europe and Japan to participate and win the Big One. The military bureaucracy grew accordingly and thousands of new jobs were created. With the military's enormous demand for personnel... ...os Angeles newspaper in March 1953 linking "sexual deviates" with "security risks" who were banding together to wield "tremendous political power". The Mattachine Society was restructured, with a more transparent organization, and its leadership replaced. It also changed its aims to the assimilation of homosexuals into general society, which reflected its rejection of the notion of a homosexual minority. However the Society declined, and at its convention in May 1954 only forty-two members attended. The Mattachine Society produced the monthly periodical ONE Magazine , starting in January 1953 and eventually achieving a circulation of 5000 copies. The regular publication of the magazine ceased in 1968, but its publisher, ONE Inc., still exists. In January, 1955 the San Francisco branch of the Mattachine Society began a more scholarly journal, Mattachine Review , which lasted for ten years. The periodicals reached previously isolated individuals and helped Mattachine to become better known nationally. Chapters functioned in a number of USA cities through the 1960s. However, they failed to adapt to the radical militantism after the Stonewall Rebellion and faded away.

Sexually Transmitted Diseases Essay -- Essays Papers

Sexually Transmitted Diseases Sexually Transmitted Diseases are an intimate part of many people’s lives. These diseases, one could say, represent a conflict between human and nature. It is a part of nature that humans are inclined to engage in sexual activity . Yet, humans are endangering themselves with the spreading of these diseases. Also, a human oriented disease can take on a life of its own, so to speak, and even turn deadly when nature takes it course. Humans have created antibiotics and other drugs to cure the diseases and help with the symptoms of these diseases, but the complications that can arise from these diseases sometimes have no cure, and it is at this time that nature takes over. Sexually transmitted diseases are a part of history. Some have been around since the beginning of the United States. During times like the Industrial Revolution, the Depression, and WWI, sexually transmitted diseases have flourished because of the conditions of the cities and the living areas of citizens. Sexually transmitted diseases, of STDs, are a growing concern among people of all ages. Some are less severe and dangerous than others, but none of them are to be taken lightly. Some of the most common diseases are Acquired Immunity Deficiency Syndrome (AIDS), which is caused by the HIV virus; Chlamydia, Gonorrhea, Herpes Simplex, and Syphilis. These facts from the STD Homepage (http:// med-www.bu.edu/people/sycamore/std.) further explain the diseases and what one can expect from them. Sexually Transmitted Diseases are serious and can have lifelong effects; however, most are easily prevented and treatable. AIDS The disease AIDS, which is a set of disease... ...elids, face, chest, fingers, breasts, anus, and on the perineum. After the chancres disappear, the disease continues to inhabit the body. Syphilis is completely curable with antibiotics. Some complications of the disease that can not be cured but that may arise are flu-like symptoms, fever, skin rash, swollen glands, spots on the tongue, and warts on the genitals. In the last stage, the syphilis eats away at skin and bones. It can cause blindness, heart disease, and brain damage. Therefore, the Humanities Base Theme of Human Vs. Nature is prevalent in the topic of sexually transmitted diseases. Although there are drugs to lessen the effects and cure most of the actual diseases themselves, some complications that may arise are not curable. These complications, which arise mainly from nature taking its course in the body, are not curable by humans.

Managing Diversity and Ethics in the Workplace Essay

Introduction There steps leaders and managers can take to effectively manage diversity and ethics concerns. How a manager effectively manages ethics and diversity, within the organization is directly correlated to the cultural, organizational and external environment influence ethical behavior. One of the step’s leaders and managers can take is to incorporate diversity training of the organization. This big step puts the organization on its way toward maintaining a well balanced diverse organizational culture within a company. When it comes to managing diversity in the workplace, there are many attributes that go into a successful training session. (Jones, 2011, p. 164), â€Å"managers can take steps to change attitudes and values and promote the effective management of diversity.† Diversity training within an organization is an effective step in changing the values and promotes the effective leadership and management of diversity within the organization is a big step towards mainta ining a well balanced diverse organizational culture within a company. Every leader of an organization implores and implements different diversity training tactics. Some companies have strict diversity training seminars that include power point presentations with a set of rules for do and don’t. Other organizations implement an more interactive method with diverse groups as a means to also reap the benefits of a diverse workforce: For example: at â€Å"Sodexo and Principle Financial Group† (Jones, 2011 p. 143) â€Å"Sodexo encourages managers like Ron Bond to interact with diverse groups to gain a better appreciation and understanding of their experience.† Sodexo acknowledged and understands that when diversity is manage effectively organizations can benefit the organization as a diverse workforce bring, diverse perspectives, points of view, experience and knowledge. Sodexo also provide their employees with extensive diversity training, which encourages managers to be mentors and interact with diverse groups. According to Sodexo web site they â€Å"At Sodexo we work around five pillars – gender, generations, disability, ethnical origins and LGBT – to foster a culture that embraces differences and celebrates unique ideas, perspectives, experiences and talents.† As we strive to challenge stereotypes and disseminate the business case for diversity, we believe it is crucial to train all managers and employees.† (Sodex 2012). â€Å"Sodexo USA’s diversity learning strategy offers awareness training and skills building labs on topics ranging from generations in the workplace to cross-cultural communications. Following the U.S. example, a program designed to heighten awareness, building skills and provide tools for managing within a diverse working environment were launched throughout Europe.† (Sodex 2012). An organization such as Deloitte & Touche, â€Å"have instituted a program to encourage minority suppliers to complete for its businesses, and the firm sponsors schools and colleges that supply a stream of well-trained recruits.† (Jones, 2011, p. 145). According to Google’s corporate website on diversity, â€Å"The Diversity training is designed to ensure our employees have the awareness, skills and knowledge to build and retain the workforce to fuel Google globally. Our diversity education programs includes all aspects surrounding employment that aim to create a culture of inclusion with a focus on improving recruitment strategies and techniques for identifying high-value diverse talent† (Google 2010). Google also says that â€Å"At Google, we are committed to a supportive work environment, where employees have the opportunity to reach their fullest potential. Each Googler is expected to do his or her utmost to create a respectful workplace culture that is free of harassment, intimidation, bias and unlawful discrimination of any kind† (Google 2010). The website goes on to say that employment at Google is based solely upon individual merit and qualifications directly related to professional  competence and is not based on the basis of â€Å"race, color, religion, veteran status, national origin, ancestry, pregnancy status, sex, gender identity or expression, age, marital status, mental or physical disability, medical condition, sexual orientation or any other characteristics protected by law† (Google 2010). This tells us that Google treats everyone equally, and gives them the same opportunities as everyone else. Equality challenging for diversity stakeholders and executives is getting the leadership team to realize and implement that things have changed harnessing cultural diversity through training increase productivity as such must be a major part of an organization. (Jones, 2011 p. 165) demonstrates number organizations are implementing programs within the organization that requires interaction. One of such organizational program whereby top managers spend time performing the same work duties as employees to improve and understand the challenges employees face was DaVita Inc. DaVita Inc., is a major supplier of kidney dialysis service, in the U.S. and while the three top seniors executives have never worked in a dialysis clinic, exchange work places and now work three days in the clinic. The executives were provided with a better insight and understanding of the nature of the technicians jobs, along with the how emotional the job is and the effects on the technicians. There is no better way to understand diverse group than interaction, joining together at certain times in order to interact and communicate. Leadership of Teams Essential important when implementing a change of the organization core values, and goals is to form a top management team. (Jones, 2011 p. 499). Top management teams are the ones responsible for developing diversity training methods and a strategy to implement the training within the organization in order to achieve the organization goals. Top management teams, are normally compose to a diverse group, with knowledge, expertise and experience in stressing diversity. As cross-functional top management team the members are comprised from the various departments within the organization as a formal group. The top management as a formal group, come together to form a cross-cultural team, by following the five stages of forming a group, as group role is to set the behaviors and task. One of the behaviors for diversity training is that the members of the  team to lead by example, in demonstrating ethical and social responsibility. By treating employees based on skills rather than age, sex or race. The integration of leadership exercises in diversity training programs will help employees realize the importance of this attribute within the organization. There are many reasons as to why there must be a diverse team of leadership from top management from different backgrounds, ethnicity, age, gender, or education so that the company can integrate points of views from people from different walks of life. In diversity training, employees would be made to realize that anyone can be a leader regardless of age, sex or race. Leadership skill workshops can be introduced at the work place to educate employees and encourage them to cultivate these skills. Many people confuse management and leadership to be the same thing. There are many people from diverse backgrounds who are managers. Management focuses on establishing detailed plans and schedules for achieving certain results, then providing resources to accomplish the plan. The jobs need to be filled with qualified individuals who understand the direction of the company. Leadership, on the other hand, creates change, often to a dramatic degree. Leadership calls for creating a more efficient or imaginative process for a future vision. While there are some managers who are leaders, there are some who are not. Being both a good manager as well as a good leader is a balance between learned concepts of leadership as well as inborn traits of a leader. One reason that leadership in diversity training is necessary is because people from different backgrounds have different life experiences. These life experiences gives character, and their character is what determines what kind of leader they will end up being. For example, a potential leader will show strong characteristics like drive, energy, determination, self-discipline, willpower and a need for excellence. On the other hand, a person with weak character will show none of these traits. Their traits will be disorganized and random, and they will attract no followers. To be an effective leader, one must be trustworthy and ethical. A supervisor or manager at a company will only be well liked and looked up to if his employees trust him. In any organization, a leader’s actions set the pace and the way a leader behaves if closely watched and noticed by his employees. This behavior wins trust, loyalty, and ensures the organization’s  continued prosperity. One of the ways to build trust is to display a good sense of character composed of beliefs, values, skills, and traits and to not be discriminatory towards people. In diversity training tactics, it might be helpful to pair those with leadership potential with other leaders from different backgrounds so that they can learn the qualities of being an effective leader from each other. It might also be interesting to note how leaders from different backgrounds and ages tackle problems. There are many ways of b eing a leader, and people with different life experiences will tackle problems in a different way, depending on the situation and their background. For example, leaders like presidents of countries operate differently from leaders of companies. In diversity training, perhaps an exercise could be undertaken that makes the employee chose a scenario and act as a leader in that scenario in order to explore different types of leadership. Diversity training workshops should also focuses on crucial leadership traits that may be of use within the organization. One leadership trait is the trait of courage. Leaders are usually unafraid of taking on challenging tasks. They display a confident calmness when under stress and plan out strategies in order to overcome obstacles in their path. People from minority backgrounds should take particular interest in this trait because they are working to get ahead in a world where they are a minority. Another example of a leadership trait is justice. Good leaders treat everyone fairly and display empathy by being sensitive to the feelings, values, interests, and well-being of others. They are non-prejudiced towards their employees and clients and make everyone feel like their voices are being heard. For example, a manager at a board meeting hears both sides of a story before deciding on a course of action. Leadership seminars are particularly important in companies with many diverse employees because leaders build a foundation in their organization, as well as build a sense of trust with their employees. In a company, the leader or manager has to make sure the culture of the organization is positive and that the work flow is productive. The most important person in shaping an organization’s culture is the leader of the organization. A leader at the executive level is the main source for the creation and implementing the culture and everything it stands for. The leader originally decides what the core values of the organization will be, how they will go about their business and what rules they will follow. He is in charge of shaping the culture and managing it. An understanding of the diversity within the organization and the knowledge of how to mold different people together it is a necessary skill for leaders trying to achieve a strategic outcome. Along with the diversity and culture of an organization, potential leaders must also pay attention to the climate of an organization. The climate is the feel of the organization as well as the individual and shared perceptions and attitudes of the organization’s members. The climate of an organization represents the beliefs about the vibe or feel of the workplace by the employees. This individual perception of the way the organization feels comes from what the people believe about the activities that occur in the organization. These activities influence both individual and team motivation and satisfaction and the employee questions the actions and principles of the leader. These directly relate to diversity because sometimes people are unsure of how to treat other at times due to the difference in religious beliefs or opinions. If a leader outlines a general code of conduct for all employees that takes into account everyone’s beliefs and expectation, a negative climate situation can be avoided. The climate of an organization should bring about a feeling of assurance to the employees; so that they know that they are doing things right and behaving appropriately. Leading Change and Managing Conflict Managing conflicts within the organization today requires the type of leader that is able to communicate and collaboration when working with a diverse workforce. Conflict is a an inevitable part of any organization, as goals of shareholders, managers and employees are more than often incompatible. (Jones, 2011, p. 566). When there is a crisis within an organization, a leader needs to be able to rise to the occasion, and bring out extraordinary leadership qualities by first determining what type of conflict is involved such interpersonal, intra group, inter group and interorganizational, understanding these various types of conflict and how they differ helps a manager deal with the conflict. Moreover a manager needs to understand the source of the conflict, whether it seem from different  goals and time horizons, overlapping authority, and/or task interdependencies. When a manager is able to discern the type of conflict and source he can focus on a fair consist distribution of justi ce equability. By cultivating leadership skills in employees, people from different cultures and backgrounds begin to trust each other because they are all leaders and they view themselves as equal to one another. The leadership aspect of diversity training should also outline how to be a respectful, unbiased leader when it comes to other cultures and ages within the organization. Employees observing a leader do not look at the traits or attributes of a leader, rather, they observe what the leader does in order to decide whether their supervisor really is a good leader or not. They use this observation to tell whether the leader is an honorable person or a self-serving person who discriminates against other people or misuses their authority in order to get a promotion. Self-serving leaders are not as effective because their employees only obey them, not follow them. On self-serving leaders, often give employees â€Å"The feeling of being separate, which is characteristic of leaders, is different from narcissism. The leader is aware of boundaries and distinguishes the inner and outer worlds, fantasy and reality, self and other people. Career-oriented managers are more likely to exhibit the effects of narcissism than leaders. While busily adapting to their environment, managers are narrowly engaged in maintaining their identity and self-esteem through others, whereas leaders have self-confidence growing out of the awareness of who they are and the visions that drive them to achieve Diversity training companies also helps cultivate relationships between the people of the organization. Organizational conflicts is a discord that arises when there is a diverse workforce who are incompatible, where goals, values and interest differ, which cause blocks and attempts to thwart each other work performance. Diversity training that address conflict management strategies focuses on conflict resolution diversity awareness, sources of conflicts, job rotation, and temporary assignments. These strategies focus on the whole organization. A Top management team position, as the leader has to make sure his employees are working togeth er as a team. Doing their share of the work, getting along with people and working well with others are all part of teamwork. A leader or manager has to make sure that  his employees are not only meeting these goals, but also motivating them to go one step ahead of these goals to increase productivity. Introduction of these concepts in relation to diversity will help people from different backgrounds work together towards a common goal. Teamwork training exercises in diversity training are important for employees who want to advance to a leadership position, as teamwork is one of the key things managers look at when determining leadership potential. Employees with leadership potential see team effectiveness as a leadership opportunity. They realize that they will achieve more by working through and with others, that they will get more done with the active support of colleagues. These exercises will also help to harbor good relations between people from different walks of life. Finally, leadership seminars motivate minorities to do better. In recent times, minority employees have been underestimated when it comes to handing out leadership positions. One reason for this is that some minorities do not think that they are capable of being leaders because there have been so few minority leaders in their organization. They do not go for higher positions because they think that they cannot get them. By organizing leadership seminars, minorities can see that they are good enough to be leaders because they are not different from any other race, culture, gender or age group around them. The leadership seminars will help them learn about their own skills as well as inculcate new ones within them so that they go for their goals. CONCLUSION Leadership is an important attribute that should be more focused on in diversity training workshops. Leadership leads to teamwork which is an important factor in an organization. Making sure that employees get along and that no one is discriminated against is a leader’s job. If everyone is taught about leadership and how it works, people from different backgrounds will gain the confidence and skills required to advance within the organization. Leadership seminars will also help to inspire people and prevent a negative cultural climate from occurring between people from different backgrounds. Activities like leadership role switching and scenario leadership can help cultivate teamwork and leadership among employees. Bibliography Jones, Gareth R. and George, Jennifer M. Contemporary Management. 7th ed. McGraw-Hill Irwin, N.Y., N.Y., 2011. Sodex (2012) Sodex and Principle Financial Group. Retrieved from http://www.sodexo.com/en/commitments/diversity-inclusion/actions/training.aspx July 20, 2012 Google (2010). Google Diversity and Inclusion. Retrieved from on July 20, 2012.